Multi-organ dysfunction in Sickle Cell Disease: a rare presentation and its management in resource-limited setting.


  • Fatma A Bakshi Department of Internal Medicine, The Aga Khan Hospital, Dar es Salaam.
  • Semvua B Kilonzo Department of Internal Medicine, Bugando Medical Centre, Mwanza
  • Daniel W Gunda Department of Internal Medicine, Bugando Medical Centre, Mwanza
  • Elichilia R Shao Department of Internal Medicine, Kilimanjaro Christian Medical Centre, Moshi-Tanzania Department of Internal Medicine, Catholic University of Health and Allied Sciences, Mwanza



Sickle cell disease, avascular necrosis, LV hypertrophy, pulmonary hypertension, chronic kidney disease, cholelithiasis


Introduction: Chronic end-organ damage among the sicklers is frequently diagnosed in Tanzania, but rarely involves multiple organs in a single patient.

Case report: A 26-year-old Tanzanian black-sickler woman presented with features related to avascular necrosis of the right hip, left ventricular hypertrophy, pulmonary hypertension, Chronic Kidney Disease and Cholelithiasis. Despite the management given, her condition is still deteriorating.

Conclusion: Prevention of these complications through screening and early diagnosis with a concurrent timely treatment should be advocated by all health-care providers


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How to Cite

Bakshi, F. A., Kilonzo, S. B., Gunda, D. W., & Shao, E. R. (2017). Multi-organ dysfunction in Sickle Cell Disease: a rare presentation and its management in resource-limited setting. Tanzania Medical Journal, 29(1), 104–114.



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