Prevalence of Incidental Prostate Carcinoma among Patients Undergoing Turp for Benign Prostatic Enlargement

Authors

  • Isaac H. Mawalla The Aga Khan Hospital
  • Masawa K. Nyamuryekung’e The Aga Khan Hospital
  • Athar Ali The Aga Khan Hospital
  • Aidan Njau The Aga Khan Hospital
  • Philip Adebayo The Aga Khan Hospital
  • Ali A. Zehri The Aga Khan Hospital

DOI:

https://doi.org/10.4314/tmj.v32i4.417

Keywords:

Incidental prostate cancer, Prevalence of incidental prostate cancer, Prostate specific antigen, Sub-Saharan Africa

Abstract

Background

Incidental prostate cancer is detected by histological examination of resected biopsy tissue that has been previously diagnosed as benign. It has the potential for progressing to become a disease necessitating active treatment. There is paucity of data on detection of incidental prostate cancer in Tanzania. A study done in northern Tanzania among the urban public sector revealed an alarming detection rate of 21.71%. We aimed to establish the prevalence of incidental prostate cancer among men surgically treated for benign prostate enlargement with considered normal range of prostate specific antigen.

 Methods

This was a retrospective hospital-based cross-sectional study conducted to establish the prevalence of incidental prostate cancer among men who underwent transurethral resection of prostate with considered normal range of prostate-specific antigen from 2010 to 2019 at Aga Khan Hospital Dar es salaam, Tanzania. To find the prevalence of incidental prostate cancer with 95% confidence level, 5% tolerable error, minimum of 195 participants’ data was reviewed, and factors associated with incidental prostate carcinoma were evaluated by binary regression analysis.

 Results

Total of 195 men were included in the study. The prevalence of incidental prostate cancer among men with prostate-specific antigen levels of less than 5.5ng/mL was 7.2% (95% CI, 4.0 to 11.8%). More than half of the patients had high-grade cancer and three quarters had T1b histological subtype making up the clinically significant category. For every 1-year increase in age from age of 65 years, risk of incidental prostate cancer increased by 1.6 (95% CI, 1.054 to 23.38; P<0.05) and for every unit increase in prostate specific antigen, incidental prostate cancer increased by 2.2 (95% CI, 1.953 to 42.28; P<0.05).

 Conclusion

The Incidental prostate cancer detection rate of 7.2% in our settings is within the range found internationally.

Author Biographies

Isaac H. Mawalla, The Aga Khan Hospital

Resident - General Surgery, Department of Surgery, The Aga Khan Hospital, Dar es salaam, Tanzania

Masawa K. Nyamuryekung’e, The Aga Khan Hospital

Instructor, Department of Surgery, The Aga Khan Hospital, Dar es salaam, Tanzania

Athar Ali, The Aga Khan Hospital

Assistant Professor and Head of Surgery, Department of Surgery, The Aga Khan Hospital, Dar es Salaam, Tanzania

Aidan Njau, The Aga Khan Hospital

Instructor and Consultant Surgeon, Department of Surgery, The Aga Khan Hospital, Dar es Salaam, Tanzania

Philip Adebayo, The Aga Khan Hospital

Assistant Professor and consultant Neurologist, Department of Internal Medicine, The Aga Khan Hospital, Dar es Salaam, Tanzania

Ali A. Zehri, The Aga Khan Hospital

Assistant Professor | Residency Program Director and Senior Consultant Urologist, Department of Surgery,  The Aga Khan Hospital, Dar es Salaam, Tanzania

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Published

2021-11-12

Issue

Section

Original Research